Amber: A Winter Gathering by Kim Hargreaves (2008-10-24) by Kim Hargreaves

By Kim Hargreaves

AMBER A iciness collecting assortment is an excellent booklet by way of Kim Hargreaves. A winter's assortment worn to dramatic influence comprises 21 clothing & components, all utilizing appealing Rowan yarns.

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2011b), as well as mice (Kamiie et al. 2008) and monkeys (Ito et al. 2011a), by means of a liquid chromatography– tandem mass spectrometric quantification method. This new technology has made it 2 Recent Progress in Blood–Brain Barrier and Blood–CSF Barrier Transport… 27 Fig. 2 Transport models at the blood–brain barrier (BBB) and blood–cerebrospinal fluid barrier (BCSFB) possible, for the first time, to measure quantitatively the absolute protein amounts of BBB transporters, including SLC transporters such as Na+-independent L-type amino acid transporter (LAT1/SLC7A5) and its associated protein (the heavy chain of the 4F2 cell-surface antigen, 4F2hc/CD98/SLC3A2), facilitative glucose transporter 1 (GLUT1/SLC2A1), and monocarboxylic acid transporter 1 (MCT1/ SLC16A1), as well as ABC transporters such as the breast cancer-resistance protein (BCRP/ABCG2), P-glycoprotein (P-gp/MDR1/ABCB1), and multidrug-resistanceassociated protein 4 (MRP4/ABCC4).

2005). This result implies that alteration of Glut1 function at the BBB may impair brain energy homeostasis. 3 33 MCT1/SLC16A1 Mct1/Slc16a1 mediates H+-coupled blood-to-brain influx transport of monocarboxylates, such as lactate and pyruvate (Kido et al. 2000). Quantitative proteomics has revealed that the expression of Mct1 at the monkey BBB is higher at the neonatal stage and is reduced in the adult (Ito et al. 2011a). Mct1 expression in rodent brain is also induced during the suckling period and by a ketogenic diet (Leino et al.

1994), implying that Glut1 is a transporter for glycosylated peptides. On the other hand, chemotherapeutic agents coupled with d-glucose (d-glucose-chlorambucil derivatives) inhibit Glut1mediated transport activity, but are not actually transported by human GLUT1 (Halmos et al. 1996). A recent study on the structure-transport activity relationship of human GLUT1 revealed that Ile287 located at transmembrane 7 (TM7) is a key residue for maintaining high glucose affinity and is located at or near the exofacial glucose-binding site (Kasahara et al.

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