By Theodora W. Greene
From the experiences of the former editions:
* "For completeness, the authors . . . comprise protecting teams and methods for formation and cleavage which are seldom used in addition to those who are extra universal. . . . somebody who does natural synthesis should have handy entry to this book." -Journal of the yankee Chemical Society.
* "Essential to the fashionable artificial natural chemist . . . can be within the libraries of all educational, governmental, and business firms desirous about natural synthesis." -Polymer News.
Reflecting the most recent advances in protecting team technique, this 3rd version of the confirmed laboratory reference is elevated by way of greater than 50%, offering readers with a finished compendium of 1,050 of the main necessary protecting teams in addition to 5,350 references to unique guides. protecting teams are equipped by way of six significant natural practical teams: hydroxyl, amino, carboxyl, carbonyl, sulfhydryl, and phosphate teams (the final new to this edition). additionally further during this variation are security of the alkyne-CH, accelerated assurance of safety of all teams, and plenty of new enzymatic tools of security and deprotection. each one bankruptcy in brief describes the periods of accessible protecting teams, via an in-depth examine the chemistry of person protecting teams, their houses, and the easiest equipment of formation and cleavage. Ten reactivity charts with greater than 28,000 entries summarize the relative reactivities of 270 familiar protecting teams with 108 reagents. This booklet may be an fundamental reference for man made chemists and scholars.
Chapter 1 The position of protecting teams in natural Synthesis (pages 1–16):
Chapter 2 defense for the Hydroxyl team, together with 1,2? and 1,3?Diols (pages 17–245):
Chapter three security for Phenols and Catechols (pages 246–292):
Chapter four security for the Carbonyl team (pages 293–368):
Chapter five security for the Carboxyl workforce (pages 369–453):
Chapter 6 security for the Thiol team (pages 454–493):
Chapter 7 safety for the Amino staff (pages 494–653):
Chapter eight defense for the Alkyne –CH (pages 654–659):
Chapter nine safety for the Phosphate team (pages 660–700):
Chapter 10 Reactivities, Reagents, and Reactivity Charts (pages 701–748):
Read Online or Download By Theodora W. Greene - Protective Groups in Organic Synthesis (3rd Edition) (1999-05-08) [Hardcover] PDF
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Extra info for By Theodora W. Greene - Protective Groups in Organic Synthesis (3rd Edition) (1999-05-08) [Hardcover]
4-Dimethoxybenzylidene acetals. 2-diols. 228 [(3,4-Dimethoxybenzyl)oxy]methyl ethers. to protect alcohols. 37 S-Dimethoxybenzyl thioethers, to protect thiols. 460 2,2-Dimethoxycarbonylvinyl carbamates. 4’-Dimethoxydiphenylmethyl thioethers. 2-Dimethoxyethylidene ortho esters. 4’-Dimethoxy-3”-[N-(imidazolylethyl)carbamoyl] trityl (IETr) ethers, to protect alcohols, 107- 108 4,4’-Dimethoxy-3”-IN-imidazolylmethyl)] trityl (IDTr) ethers. to protect alcohols. 4-Dimethoxy-6-nitrobenzyl carbamates. 4-Dimethoxyphenylamides.
As sulfonium salts, 49 l-493 4-Sulfobenzyl esters, to protect carboxyl groups, 426-427 9-(2Sulfo)fluorenylmethyl carbamates. to protect amines, 507 Sulfonamides, to protect amines, 603-615. 615-617 Sulfonate esters: to protect alcohols, 197-200 to protect phenols, 285-287 to protect thiols. 615-617 Sulfur-containing derivatives: to protect alcohols, 197-200 to protect amines, 286,600-615 to protect carbonyl groups, 329-347 to protect carboxylic acids, 43 l-433 to protect phenols, 285-287 to protect phosphates.
1 to protect amino, carboxyl, and side-chain functional groups in amino acids (list), 373 reactivities, 70 1, 705-707 selection of, 6-7,705-707 silyl derivatives, to protect alkynes. 655-657 silyl esters, to protect carboxylic acids, 428-43 1 silyl ethers: to protect alcohols, 113- 148 to protect diols, 237-241 to protect phenols, 273-276 silyl thioethers, to protect thiols, 482 sulfonates: to protect alcohols, 197-200 to protect phenols, 285-287 to protect thiols, 488 thiocarbamates, to protect thiols.