Brain Tumor Invasiveness by Unnur P. Thorgeirsson, Carol K. Lindsay, David W. Cottam

By Unnur P. Thorgeirsson, Carol K. Lindsay, David W. Cottam (auth.), Ronald H. Goldfarb (eds.)

It is broadly favored that the pathophysiology of complex mind melanoma is in detail concerning the level of tumor invasiveness. A prerequisite for comprehensively figuring out neuro-oncology is for that reason the elucidation of the biochemical and molecular homes of tumor cells that give a contribution to their invasiveness. An knowing of tumor invasion for critical fearful procedure tumors is essential in view that malignant mind tumors are very hugely invasive and commonly smash adjoining neural mind tissue. in addition, they're angiogenesis-dependent and bring about the dying of sufferers through increasing in the restricted house of the skull. As extra particular insights are won in the direction of an entire figuring out of the advanced strategy of tumor invasiveness of mind tumor cells, it's going to be attainable to layout recommendations for the early prognosis and remedy of invasive, complicated mind tumors. there's for this reason an pressing have to higher comprehend the mobile homes of mind tumor cells chargeable for invasiveness.
This certain factor of the JOURNAL OF NEURO-ONCOLOGY presents a cutting-edge overview of the final figuring out of the method of tumor invasion. additionally, the articles emphasize particular facets of competitive mind cancers that are really vital for deriving new insights for healing methods for complex mind melanoma that would objective tumor invasiveness. the tips mentioned will stimulate extra experiences directed in the direction of the interpretation of those very important invasion-related reviews to medical techniques for the powerful therapy of mind melanoma.

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J Natl Cancer Inst 82: 589-595, 1990 Ponton A, Coulombe B, Skup D: Decreased expression of tissue inhibitor of metalloproteinases in metastatic tumor cells leading to increased levels of collagenase activity. Cancer Res 51: 2138-2143,1991 Nakajima M, Lotan D, Baig MM, Carralero RM, Wood WR, Hendrix MJC, Lotan R: Inhibition by retinoic acid of type IV collagenolysis and invasion through reconstituted basement membrane by metastatic rat mammary adenocarcinoma cells. Cancer Res 49: 1698-1706, 1989 Hendrix MJC, Wood WR, Seftor EA, Lotan D, Nakajima M, Misiorowski RL, Seftor REB, Stetler-Stevenson WG, Bevacqua SJ, Liotta LA, Sobel ME, Raz A, Lotan R: Retinoic acid inhibition of human melanoma cell invasion through a reconstituted basement membrane and its relation to decreases in the expression of proteolytic enzymes and motility factor receptor.

This group includes medulloblastoma, malignant ependymoma, choroid plexus carcinoma and intracranial germinoma. The primary site for these tumors is almost always in contact with ventricular CSF, perhaps explaining the propensity for this type of tumor spread. In fact, one study has suggested that cell entry into the intraventricular space during surgery may increase the risk of tumor spread along CSF pathways [75]. Besides shedding into the CSF, tumor cells that spread in this way must also be able to attach at a distant CNS sites and invade the site of attachment.

MMPs and TIMPs are secreted by glioma cells in culture [56] and increased levels of MMPs, in particular gelatinase B, have been found in human tumor tissue specimens [28] of glioblastoma but not meningioma, astrocytoma or in normal brain [57]. The presence of a metalloenzyme, inhibited by 1,1O-phenanthroline (an inhibitor of metalloproteases), in highly invasive rat C6 glioblastoma cells is responsible for their invasiveness in an in vitro model for CNS white matter invasion [58]. Further supporting an active role of MMPs in invasion, investigators have shown that TIMP-2, an inhibitor of metalloproteinases, reduces the proteolytic opening of the blood brain barrier by tumor cells [59].

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