Brain Hypothermia: Pathology, Pharmacology, and Treatment of by Nariyuki Hayashi (auth.), Nariyuki Hayashi M.D., Ph.D.

By Nariyuki Hayashi (auth.), Nariyuki Hayashi M.D., Ph.D. (eds.)

Rapid development in know-how and its software to prognosis and tracking of mind tissue temperature and metabolism have ended in advances within the treatment for severely brain-injured sufferers and breakthroughs in realizing the pathophysiology of mind harm. the most recent suggestion of mind hypothermia remedy clarifies objectives corresponding to mind thermal pooling, protecting mind hypoxia linked to catecholamine surge, the metabolic shift from glucose to lipids, and selective radical harm of dopamine within the critical anxious approach. This quantity explains the mechanism of mind harm and the way mind hypothermia remedy differs from different hypothermia remedy in 4 significant sections: mind harm Mechanism, Pathophysiology of Hypothermia, uncomplicated examine of Hypothermia remedy, and scientific stories of mind Hypothermia. The publication is a necessary resource for practitioners and researchers in neurosurgery and neurology and in serious care and emergency medicine.

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Marion DW, Obrist WD, Carlier PM, Penrod LE, Darby JM (1993) The use of moderate therapeutic hypothermia for patients with severe head injuries: A preliminary report. J Neurosurg 79:354-362 42. Marion DW, Penrod LE, Kelsey SF, Obrist WD, Kochanek PM, Palmer AM, Wisniewki SR, DeKosky ST (1997) Treatment of traumatic brain injury with moderate hypothermia. N Eng J Med 336:540-546 43. Marion DW, White MJ (1996) Treatment of experimental brain injury with moderate hypothermia and 21-aminosteroids. J Neurotrauma 13:139-147 44.

Jiang JY, Lyeth BG, Kapasi MZ, Jenkins LW, Povlishock JT (1992) Moderate hypothermia reduces blood-brain barrier disruption following traumatic brain injury in the rat. Acta Neuropathol 84:495-500 38. Kamme F, Camp ell K, Wieloch T (1995) Biphasic expression of the Fos and Jun families of transcription factors following transient forebrain ischaemia in the rat: Effect of hypothermia. European J Neurosci 7:2007-2016 39. Koizumi H, Povlishock JT (1998) Posttraumatic hypothermia in the treatment of axonal damage in an animal model of traumatic axonal injury.

HP contents in the culture media were measured 6 days after treatment. Vertical and horizontal axes show HP contents (% of control) and hormone concentrations (M), respectively FIG. I. The involvement of hormones and glands in hibernation has been investigated in detail [5,18). As thyroxine has important effects on metabolism and thermogenesis, many studies have been carried out in hibernators. Most of these studies suggested that thyroid activity is depressed during hibernation, although a few studies demonstrated that thyroid function continued during hibernation [3).

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