Bioreactor Systems and Effects, 1st Edition by R. Bliem, K. Konopitzky, H. Katinger (auth.)

By R. Bliem, K. Konopitzky, H. Katinger (auth.)

Contents: R.F. Bliem, Syracuse, big apple; ok. Konopitzky, H.W.D. Katinger, Wien, Austria: Industrial Animal phone Reactor Systems: points of choice and Evaluation.- H.N. Chang, Seoul, Korea; S. Furusaki, Tokyo, Japan: Membrane Bioreactors: current and Prospects.- J.C. Merchuk, Beer Sheva, Israel: Shear results on Suspended Cells.- M.R. Johns, P.F. Greenfield, H.W. Doelle, St. Lucia, Australia: Byproducts from Zymomonas mobilis.- V. Kren, Prague, CSFR: Bioconversions of Ergot Alkaloids.

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4 Oxygen Transfer Systems . . . . . . . . . . . . . . . . . . . . . . . 5 Commercial Animal Cell Culture Systems . . . . . . . . . . . . . . . . 6 Plant Cell Culture Systems . . . . . . . . . . . . . . . . . . . . . . correspondence should be addressed. Advances in Biochemical Engineering Biotechnology, Vol. 44 Managing Editor: A. Fiechter 9 Springer-Verlag Berlin Heidelberg I991 28 7 8 9 10 Ho Nam Chang and Shintaro Furusaki Concluding Remarks .

In a membrane system where a flat membrane is employed, concentration polarization on the membrane surface is a common phenomenon. Membrane spacers promote mixing of fluids between the two membranes [21-23]. The role of membrane spacers and its mass transfer effect are reviewed elsewhere [17]. == AP(z)=P(z)-Po(= P1ยง 2 ) Fig. 6. 0 kg cm -2 LINEAR VELOCITY, ~'~" 20 - 9 " cm Fig. 7. 3 I I I -~= 20 I 100 LINEAR VELOCITY, cm s -I o : 59 z,: 42 ~ u I 1 3 10 30 CELL CONCENTRATION, g 1-1 : 9 22 -g 10 ~o 0~ 013 b I l I I 3 10 30 100 CELL CONCENTRATION, g [-I Fig.

59 60 60 61 Membrane bioreactors have a very handy in-situ separation capability lacking in other types of bioreactors. Combining various functions of membrane separations and biocatalyst characteristics of enzymes, microbial cells, organelles, animal and plant tissues can generate quite a number of membrane bioreactor systems. The cell retaining property of membranes and selective removal of inhibitory byproducts makes high cell density culture possible and utilizes enzyme catalytic activity better, which leads to high productivity of bioreactors.

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