By Professor Thomas Unger, Professor Bernward A. Schölkens (auth.)
Nearly thirty years in the past, in 1974, the quantity on Angiotensin edited through Irvine H.Page and F. Merlin Bumpus extended the guide of Experimental Pharmacology. Even after 20 years the multiplicity of its activities appears to be like to not were totally found. to name recognition to its many capabilities is likely one of the reasons of this booklet. This new version of the quantity on Angiotensin makes an attempt to supply an up-to-date account of the data and findings amassed because the complexity of angiotensin used to be so safely recognized.
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42 43 44 44 47 48 49 51 52 Abstract Extracellular matrix (ECM) is an important structural and functional constituent of both healthy and diseased blood vessels. Vascular cells are embedded in the multicomponent network of the ECM that contains collagens, other glycoproteins, proteoglycans and carbohydrates. The interaction between embedded cells and ECM is mediated through specific transmembrane receptors such as integrins or syndecans.
40 2 Focal Adhesion Complexand Cellular Phenotype . . . 4 Modulation of ECM-Mediated Signals by ANG AT2 Receptorand Vascular ECM . . . . Modulation of Expression . . . . . . Fibronectin . . . . . . . . . . Collagen . . . . . . . . . . . Proteoglycans . . . . . . . . . Induction of Autocrine Factors . . . . . Inhibition of ECM Turnover . . . . . Modulation of Focal Adhesion Signaling. . 4 Summary and Conclusion .
The question arises of whether lL-6 is only a marker or in fact a mediator. , PAl-l} and the stimulation of matrix degrading enzyme s, such as MMP-l and MMP-9 (Kishimoto et al. 1995; Solis-Herruzo et al. 1996). A recent report by Rekhter and eo-workers demonstrated that the delicate balan ce of plaque stability is controlled, on one hand, by intrinsic properties of the tissue and, on the other hand, by externa l forces to which the plaqu e is subjected (Rekhter et al. 2000). Based on this evidence, increased lipid content and decrea sed collagen content have been long suspected to decrease the mechanical 28 H.