Adjuvant Therapies and Markers of Post-Surgical Minimal by J. Lemerle, M. F. Tournade, C. Patte (auth.), Professor

By J. Lemerle, M. F. Tournade, C. Patte (auth.), Professor Gianni Bonadonna, Professor Georges Mathé, Professor Sydney E. Salmon (eds.)

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Nineteen of the patients could be followed during childhood from birth to onset of the disease. No preponderance of tall individuals could be noted nor any significant difference from expected growth curves at the time of diagnosis. The latter finding could be confirmed from teeth eruption curves, which show a high correlation with somatic development. Some patients simultaneously displayed insulin resistance and an elevated level of somatomedins A and B in the plasma. This endocrinologic study is continuing.

Thus, both the decrease of the dUR incorporation and the increase of the dTR incorporation into the DNA serve as biochemical parameters of the MTX effect [181. Normally, the incorporation rates of dUR and dTR are almost equal. 3 [18]). 1 at high MTX concentrations. The quotient dUR/dTR has proved to be a direct indicator for the effectiveness of MTX. The described biochemical effects of MTX can be corrected by the administration of its antidote citrovorum factor (CF) since this activated folate derivative directly enters the pool of the activated one-carbon units [171.

0 ........... 'I'~ I- Z W .. ••• .. FII· .. ·J···· .. ) a: w 25 Q.. g+-------r-----~------,-------r-----_, II 12 24 36 48 MONTHS FROM START OF ADRIA --------- ••••••••••••• <5 C/f 5 -111 C/f ~1I' C/f 111/17 1tEO-15 1105. 8m ItEO 1101 flEIICHED 111/18 HEll-18 "D5. Fig. 3. Percent of patients with osteosarcoma remaining disease-free after surgery and adriamycin (all patients) according to primary tumor size 21 Adjuvant Therapy of Osteosarcoma-Cancer and Leukemia Group B Experience Table 3. 4) 14 14 Tumor size (cm) 5 5-10 10 2 (14) 7 (50) 5 (30) 5 (26) 9 (47) 5 (26) Size not recorded 4 10 percentage of patients < 16 years old with tumor size < 5 cm in diameter were found in the protocol deviation group compared to the protocol adherence group.

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